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levofenfluramine

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The answer LEVOFENFLURAMINE has 0 possible clue(s) in existing crosswords.

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There are 16 letters in LEVOFENFLURAMINE ( A1E1F4I1L1M3N1O1R1U1V4 )

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10 letters out of LEVOFENFLURAMINE

FUNNELFORM MAVOURNEEN UNLOVELIER

9 letters out of LEVOFENFLURAMINE

EFFLUVIAL ENAMELLER ENLIVENER FLAVORFUL FULLERENE LIVERLEAF MANOEUVRE MAVOURNIN MUFFINEER REINFLAME UNMANLIER VENIREMAN VENIREMEN

8 letters out of LEVOFENFLURAMINE

ALEURONE ALLUVION EFFLUVIA ENAMELER ENROLLEE EVENFALL FILENAME FLANERIE FLUORENE FLUORINE FOREFEEL FORENAME FORMALIN FORMULAE FRAULEIN FUMAROLE FUNEREAL INFERNAL INFLAMER INFORMAL LANOLINE LEMURINE LIMONENE LINOLEUM LONELIER LOVELIER MANEUVER MEUNIERE MONELLIN NEURONAL NONLEVEL NONRIVAL NONVIRAL NOUMENAL NOUVELLE OVERFILL OVERFULL OVERLAIN OVERLEAF OVERMINE REFALLEN RELUMINE REVEILLE REVENUAL RIFLEMAN RIFLEMEN UNEVENER UNFALLEN VELARIUM VENEREAL VOMERINE

7 letters out of LEVOFENFLURAMINE

AILERON ALEURON ALIENEE ALIENER ALIENOR ALIFORM ALLOVER ALMONER ALUMINE ALVEOLI ANEMONE ANEURIN AUREOLE EARMUFF ELOINER ELUVIAL ENAMINE ENAMOUR ENFEVER ENFLAME ENFRAME ENLIVEN ENVENOM ENVIRON EVILLER FAILURE FEARFUL FELAFEL FEMORAL FENNIER FENURON FERMION FERULAE FILAREE FIREMAN FIREMEN FLAMIER FLANEUR FLANNEL FLAVINE FLAVONE FLAVOUR FLEURON FLUORIN FLUVIAL FOAMIER FORAMEN FOREMAN FOREMEN FORMFUL FORMULA FRAENUM FREEMAN FREEMEN FRENULA FUELLER FULMINE FUNERAL FUNFAIR FUNNIER INFERNO INFLAME INNERVE IRONMAN IRONMEN LANOLIN LEAFIER LEAVIER LEONINE LEVELER LEVULIN LIFEFUL LINEMAN LINEMEN LINURON LIVENER LOAMIER LUMENAL LUMINAL MANILLE MANLIER MARLINE MEALIER MELANIN MILLRUN MINERAL MOANFUL MONERAN MORAINE MORELLE MORULAE MOUILLE MUFFLER MULLEIN MULLION NERVINE NERVULE NEURINE NEUROMA NEURONE NOMINAL NOMINEE NONFARM NONFUEL NONLIFE NOUMENA NOVELLA NOVELLE NOVENAE NUMERAL OFFLINE OLEFINE OVERALL OVERLIE OVERMAN OVERMEN RALLINE RAVELIN RELIEVE RELIEVO RELLENO REMOVAL REUNION REVALUE REVENUE ROMAINE ROUILLE RUFFIAN RUMINAL UNIFORM UNLEARN UNLEVEL UNMORAL UNNERVE UNRAVEL UNREEVE UNROVEN VARIOLE VEALIER VEINULE VELAMEN VENOMER VENULAR VERMEIL VERMIAN

6 letters out of LEVOFENFLURAMINE

AFFINE AFFIRM AIMFUL AIRMEN ALEVIN ALINER ALLIUM ALLURE ALMNER ALUMIN ALUMNI ALVINE AMNION ANNULI ANOMIE AREOLE ARMFUL AVENUE EARFUL EELIER ELEVEN ELEVON ELMIER ELUVIA ENAMEL ENAMOR ENROLL ENVIER ENVIRO EOLIAN EONIAN ERMINE EVENER EVILER FAERIE FAILLE FAINER FALLEN FALLER FAMINE FAMULI FANION FANNER FARFEL FAVOUR FEELER FELINE FELLER FELLOE FEMALE FEMORA FENNEL FERIAE FERIAL FERINE FERLIE FERULA FERULE FILLER FILMER FINALE FIRMAN FLAMEN FLAMER FLAVIN FLAVOR FLORAE FLORAL FLORIN FOAMER FOEMAN FOEMEN FOLIAR FOLIUM FORMAL FORMEE FOULER FOVEAE FOVEAL FRENUM FRIVOL FUELER FULFIL FULLAM FULLER FULMAR FUMIER FUNNEL FUNNER FURANE ILLUME INANER INFALL INFARE INFORM IREFUL LANNER LARINE LAUREL LAVEER LEANER LEAVEN LEAVER LEVIER LIEFER LIENAL LIERNE LIEVER LIMNER LINEAL LINEAR LOAFER LOANER LOMEIN LOREAL LOUVER LOUVRE LUMINA LUNIER MAILER MALINE MALLEE MALLEI MANFUL MANNER MANURE MARINE MARLIN MARVEL MAULER MEALIE MEANER MEANIE MELENA MENIAL MERINO MERLIN MERLON MILLER MOANER MOILER MOLINE MOLLIE MORALE MOREEN MORULA MOULIN MUFFIN MUFFLE MULLEN MULLER MUREIN MURINE NAILER NAIVER NARINE NELLIE NEROLI NEURAL NEURON NIELLO NIFFER NOMINA NORMAL NOUNAL NOVENA NUMINA OEUVRE OILMAN OILMEN OLEFIN OLEINE ONLINE OVULAR RAFFLE RAVINE REFALL REFEEL REFELL REFILE REFILL REFILM REFINE REFUEL RELEVE RELIEF RELINE RELIVE RELOAN RELUME REMAIL REMAIN REMOVE RENAIL RENAME RENVOI REVEAL REVILE RIFFLE RONNEL RUFFLE RUMINA RUNNEL RUNOFF UNEVEN UNFAIR UNFREE UNLIVE UNNAIL UNREAL UNREEL UNROLL UNROVE UNVEIL UREMIA URINAL VAINER VALINE VALOUR VALUER VANMEN VANNER VEALER VEILER VEINAL VEINER VELLUM VELOUR VELURE VENEER VENENE VENIAL VENINE VENIRE VENULE VERMIN VERNAL VILLAE VINEAL VOLUME

5 letters out of LEVOFENFLURAMINE

AERIE AFIRE AFORE AFOUL AIMER AIVER ALIEN ALINE ALIVE ALLEE ALOIN ALONE AMEER AMINE AMINO AMNIO AMOLE AMOUR ANELE ANILE ANIME ANION ANNUL ANOLE ANVIL ARENE ARIEL AUREI AVION EERIE ELAIN ELEMI ELFIN ELOIN ELVER EMAIL EMEER ENEMA ENNUI ENORM ENROL ENURE ENVOI ERVIL FANON FANUM FARLE FAUVE FAVOR FELLA FELON FEMUR FERAL FERIA FERMI FEUAR FEVER FIFER FILAR FILER FILLE FILLO FILUM FINAL FINER FIVER FLAIL FLAIR FLAME FLARE FLEAM FLEER FLIER FLORA FLOUR FLUME FLUOR FOLIA FORAM FORME FORUM FOVEA FRAIL FRAME FRENA FRILL FUMER FURAN ILEAL ILEUM ILLER INANE INARM INFER INFRA INNER INRUN INURE INURN INVAR IRONE LAEVO LAMER LAREE LARUM LAVER LEARN LEAVE LEMAN LEMON LEMUR LEONE LEVEE LEVEL LEVER LEVIN LIANE LIEVE LIFER LIMAN LIMEN LINEN LINER LINUM LIVEN LIVER LIVRE LLANO LONER LORAL LORAN LOUIE LOUMA LOVER LUFFA LUMEN LUNAR MAILE MAILL MANOR MAUVE MAVEN MAVIE MAVIN MELEE MELON MERLE MIAOU MIAUL MILER MILLE MINAE MINER MINOR MOIRA MOIRE MOLAL MOLAR MONIE MORAE MORAL MOREL MOURN MOVER MOVIE MULLA MURAL NAEVI NAIRU NAIVE NAMER NAVEL NEROL NERVE NEUME NEVER NIEVE NIVAL NOMEN NORIA NOVAE NOVEL NUMEN OFFAL OFFER OILER OLEIN OLEUM OLIVE ONIUM ORIEL OURIE OVINE OVULE RAMEE RAMEN RAMIE RANEE RAVEL RAVEN RAVIN REALM REAVE REEVE REFEL REIVE REMAN RENAL RENIN REOIL REVEL REVUE RIFLE RILLE RIVAL RIVEN ROMAN ROUEN ROVEN RUFFE RUMEN ULEMA ULNAE ULNAR UNARM UNION UNMAN URAEI UREAL URIAL URINE UVEAL VALOR VALUE VEENA VELAR VELUM VENAE VENAL VENIN VENOM VENUE VILER VILLA VIMEN VINAL VIOLA VIRAL VIREO VOILA VOILE VOLAR VOMER

4 letters out of LEVOFENFLURAMINE

AEON AERO AIRN ALEE ALEF ALIF ALME ALOE ALUM AMEN AMIE AMIN AMIR ANIL ANON ARIL ARUM ARVO AVER EARL EARN EAVE ELAN EMEU EMIR ENOL ENUF ERNE EURO EVEN EVER EVIL FAIL FAIN FAIR FALL FAME FANE FANO FARE FARL FARM FARO FAUN FAVE FEAL FEAR FEEL FELL FEME FERE FERN FIAR FIEF FIFE FILA FILE FILL FILM FILO FINE FINO FIRE FIRM FIRN FIVE FLAM FLAN FLEA FLEE FLIR FLOE FLUE FOAL FOAM FOIL FOIN FORA FORE FORM FOUL FOUR FRAE FREE FROE FROM FUEL FULL FUME FURL ILEA INFO INRO IRON LAIN LAIR LAME LANE LARI LAVE LEAF LEAL LEAN LEAR LEER LENO LEVA LEVO LIAR LIEF LIEN LIER LIEU LIFE LILO LIMA LIME LIMN LIMO LINE LINN LINO LION LIRA LIRE LIVE LOAF LOAM LOAN LOIN LONE LORE LORN LOUR LOVE LUFF LUMA LUNA LUNE LURE MAIL MAIN MAIR MALE MALL MANE MANO MARE MARL MAUL MAUN MEAL MEAN MELL MENO MENU MEOU MERE MERL MIEN MIFF MILE MILL MILO MINA MINE MIRE MOAN MOIL MOLA MOLE MOLL MORA MORE MORN MOUE MOVE MUFF MULE MULL MUNI MUON MURA MURE NAFF NAIF NAIL NAME NAOI NAVE NEAR NEEM NEIF NEMA NENE NEON NEUM NEVE NEVI NILL NINE NOEL NOIL NOIR NOMA NOME NONA NONE NORI NORM NOUN NOVA NULL NURL OLEA OLLA OMEN OMER ORAL ORLE OVAL OVEN OVER OVUM RAFF RAIL RAIN RALE RAMI RANI RAVE REAL REAM REEF REEL REIF REIN RIAL RIEL RIFE RIFF RILE RILL RIME RIVE ROAM ROAN ROIL ROLE ROLF ROLL ROUE ROVE RUFF RUIN RULE RUNE ULAN ULNA ULVA UNAI UREA UVEA VAIL VAIN VAIR VALE VANE VEAL VEER VEIL VEIN VELA VENA VERA VIAL VIER VILE VILL VINA VINE VINO VIOL VIRL VOLE

3 letters out of LEVOFENFLURAMINE

AFF AIL AIM AIN AIR ALE ALL AMI AMU ANE ANI ARE ARF ARM AVE AVO EAR EAU EEL EFF ELF ELL ELM EME EMU EON ERA ERE ERN EVE FAN FAR FEE FEM FEN FER FEU FIE FIL FIN FIR FLU FOE FON FOR FOU FRO FUN FUR IFF ILL INN ION IRE LAM LAR LAV LEA LEE LEI LEU LEV LIE LIN LUM LUV MAE MAN MAR MEL MEN MIL MIR MOA MOL MON MOR MUN NAE NAM NAN NEE NIL NIM NOM NOR NUN OAF OAR OFF OIL OLE ONE ORA ORE OUR OVA RAI RAM RAN REE REF REI REM REV RIA RIF RIM RIN ROE ROM RUE RUM RUN URN VAN VAR VAU VEE VIA VIE VIM VOE VUM

2 letters out of LEVOFENFLURAMINE

AE AI AL AM AN AR EF EL EM EN ER FA FE IF IN LA LI LO MA ME MI MO MU NA NE NO NU OE OF OI OM ON OR RE UM UN

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Definitions of levofenfluramine in various dictionaries:

LEVOFENFLURAMINE - Levofenfluramine (INN), or (−)-3-trifluoromethyl-N-ethylamphetamine, also known as (−)-fenfluramine or (R)-fenfluramine, is a drug of the amphet...

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Levofenfluramine description
Levofenfluramine (INN), or (−)-3-trifluoromethyl-N-ethylamphetamine, also known as (−)-fenfluramine or (R)-fenfluramine, is a drug of the amphetamine family that, itself (i.e., in enantiopure form), was never marketed. It is the levorotatory enantiomer of fenfluramine, the racemic form of the compound, whereas the dextrorotatory enantiomer is dexfenfluramine. Both fenfluramine and dexfenfluramine are anorectic agents that have been used clinically in the treatment of obesity (and hence, levofenfluramine has been as well since it is a component of fenfluramine). However, they have since been discontinued due to reports of causing cardiovascular conditions such as valvular heart disease and pulmonary hypertension, adverse effects that are likely to be caused by excessive stimulation of 5-HT2B receptors expressed on heart valves.Dexfenfluramine is believed to be solely responsible for the appetite suppressant properties of fenfluramine, of which it has been demonstrated to mediate predominantly via activation of postsynaptic 5-HT1B and 5-HT2C receptors through a combination of indirect serotonin releasing agent and direct serotonin receptor agonist activities (the latter of which are mediated fully by its active metabolite dexnorfenfluramine). Contrarily, levofenfluramine is thought to contribute only to unwanted side effects. Paradoxically, however, it has been shown that levofenfluramine too acts as a relatively potent releaser of serotonin, though with approximately 1/3rd of the efficacy of dexfenfluramine, As such, it would be expected to possess some degree of appetite suppressant properties as well, yet it does not. A potential explanation as to why levofenfluramine is not similarly an effective anorectic is that it has also been found to behave as a dopamine receptor antagonist, which, as dopamine antagonists like atypical antipsychotics are associated with causing increased appetite and weight gain—effects that their actions on dopamine receptors have been implicated in playing a role in the development of, is an action that could in theory cancel out the hypothetical serotonergically-mediated appetite suppressant effects of the compound. However, this is speculation and has not been proven.
* Levonorfenfluramine, an active metabolite of levofenfluramine, is also a fairly potent serotonin releasing agent (with a potency of approximately 1/2 that of norfenfluramine and 1/6th that of dexfenfluramine) and, similarly to dexnorfenfluramine, is a 5-HT2B and 5-HT2C receptor agonist, as well as a somewhat less potent norepinephrine reuptake inhibitor (about 1/2 that of its efficacy as a serotonin releaser). As such, likely contributes significantly to the biological activity—though not necessarily appetite suppressant effects—of not only levofenfluramine but of racemic fenfluramine as well. In contrast to levonorfenfluramine, levofenfluramine is virtually inactive as a reuptake inhibitor or releaser of norepinephrine, and neither ...
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