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theralizumab

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The answer THERALIZUMAB has 0 possible clue(s) in existing crosswords.

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The word THERALIZUMAB is NOT valid in any word game. (Sorry, you cannot play THERALIZUMAB in Scrabble, Words With Friends etc)

There are 12 letters in THERALIZUMAB ( A1B3E1H4I1L1M3R1T1U1Z10 )

To search all scrabble anagrams of THERALIZUMAB, to go: THERALIZUMAB?

Rearrange the letters in THERALIZUMAB and see some winning combinations

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9 letters out of THERALIZUMAB

AZIMUTHAL BRUTALIZE HEMATURIA RHEUMATIZ TULAREMIA

8 letters out of THERALIZUMAB

AMBULATE AUBRETIA AUBRIETA HABITUAL HALUTZIM HAMULATE HAULMIER LAZURITE MATERIAL THURIBLE

7 letters out of THERALIZUMAB

AMATEUR AMIABLE AMIRATE ARABIZE AZIMUTH AZURITE BALMIER BIMETAL BLATHER BLITHER BLITZER BRULZIE BUMELIA HABITUE HALBERT HALIBUT HAMULAR HATABLE HAULIER HEMATAL HETAIRA HIRABLE HUMBLER HUMERAL IMBLAZE IMBRUTE LABARUM LABIATE LAMBERT LAMBIER LATHIER LAZARET LIBRATE LIMBATE LUTHIER MALTIER MARITAL MARLITE MARTIAL MURIATE MUTABLE RATABLE REBUILT TABLEAU TABULAR TAMABLE TAMBURA TERBIUM THALAMI THERMAL THIMBLE TIMARAU TIMBALE TIMBRAL TIMBREL TREHALA TRIABLE TUMBLER TUMBREL TUMBRIL URAEMIA URALITE

6 letters out of THERALIZUMAB

ABATER ABELIA ABLATE ABLAUT ABLAZE ABULIA AERIAL ALARUM ALBEIT ALBITE ALTHEA AMBARI AMBLER AMRITA AMULET ARABLE ARBUTE ARMLET ATRIAL ATRIUM AURATE BAALIM BAILER BAITER BARITE BARIUM BARMIE BATEAU BATHER BEMATA BERTHA BHARAL BLAMER BLAZER BLITHE BRAHMA BRAIZE BRAZIL BREATH BRUMAL BRUTAL BURIAL BUTLER ERBIUM HABILE HAEMAL HAILER HALERU HALITE HALTER HALUTZ HAMATE HAMAUL HAMLET HAMULI HARTAL HAULER HAZIER HAZMAT HELIUM HERBAL HERMAI HERMIT HIATAL HIEMAL HUMATE HUMBLE HUMERI HURTLE IMARET IMBRUE ITERUM LABIUM LABRET LABRUM LAMBER LAMBIE LAMIAE LARIAT LATHER LATRIA LAURAE LAZIER LIBRAE LIMBER LITHER LUMBAR LUMBER MAILER MALATE MALTHA MARBLE MATIER MATURE MATZAH MAULER MAZIER MEATAL MIHRAB MILTER MITHER MITRAL MULETA RAMATE RAMBLA RAMBLE RAMTIL REALIA REBAIT REMAIL RETAIL RETIAL RHUMBA RIBLET RITUAL RUBATI RUMBLE RUTILE TABULI TAILER TAMALE TAMARI TAMBUR TELIUM TERBIA THAIRM THALER THIRAM THULIA TIMBAL TIMBER TIMBRE TRAMEL TRAUMA TRIBAL TUMBLE ULTIMA UMBRAE UMBRAL UREMIA ZAREBA ZARIBA ZIBETH ZITHER

5 letters out of THERALIZUMAB

ABATE ABEAM ABLER AIMER AIRTH ALARM ALATE ALBUM ALERT ALMAH ALMEH ALTAR ALTER AMAZE AMBER AMBIT AMBLE AMEBA ARAME AREAL ARHAT ARIEL ARMET ARTAL ARTEL ATRIA AURAE AURAL AUREI AZURE BAITH BAIZA BAIZE BALER BATHE BAZAR BEAUT BERTH BEZIL BIMAH BIRLE BIRTH BITER BLAME BLARE BLATE BLAZE BLEAR BLEAT BLITE BLITZ BLUER BLUET BLUME BLURT BRAIL BRAZA BRAZE BREAM BRITH BRUIT BRUME BRUTE BUILT BURET BUTLE EARTH EMAIL EMBAR HABIT HALER HALMA HAMAL HAMZA HAREM HATER HAULM HAUTE HAZEL HAZER HEART HEMAL HERMA HERTZ HILAR HILUM IHRAM ILEUM IMBUE IRATE ITHER LAARI LABIA LABRA LAHAR LAITH LAMER LAMIA LARUM LATER LATHE LATHI LAURA LAZAR LEHUA LEMUR LIBER LIBRA LIMBA LITER LITHE LITRE LUTEA MAILE MAIZE MALAR MARIA MATER MATZA MAZER MBIRA MERIT METAL MIAUL MILER MIRTH MIRZA MITER MITRE MURAL MUTER RABAT RAITA RAMAL RAMET RAMIE RATAL RATEL RATHE REALM REATA REBUT REHAB RELIT REMIT RETIA RHEUM RHUMB RIATA RUBEL RUBLE RUMBA TABER TABLA TABLE TALAR TALER TAMAL TAMER TELIA TERAI THARM THEIR THERM THIRL THRUM THUMB THURL TIARA TILER TIMER TRAIL TRIAL TRIBE TUBAE TUBAL TUBER ULAMA ULEMA ULTRA UMBEL UMBER UMBRA URAEI URATE URBIA UREAL URIAL UTERI UTILE ZAIRE ZAMIA ZEBRA ZIBET ZIRAM

4 letters out of THERALIZUMAB

ABET ABLE ABRI ABUT AHEM AIRT ALAE ALAR ALBA ALIT ALMA ALME ALUM AMAH AMIA AMIE AMIR AREA ARIA ARIL ARUM ATMA AURA BAAL BAHT BAIL BAIT BALE BALM BARE BARM BATE BATH BEAM BEAR BEAT BEAU BELT BEMA BERM BETA BETH BHUT BIER BILE BIMA BIRL BITE BIZE BLAE BLAH BLAM BLAT BLET BLUE BLUR BRAE BRAT BRIE BRIM BRIT BRUT BUHL BUHR BURA BURL BUTE EARL EATH ELHI EMIR EMIT ETUI HAAR HABU HAEM HAET HAIL HAIR HALE HALM HALT HAME HARE HARL HARM HART HATE HAUL HAUT HAZE HEAL HEAR HEAT HEIL HEIR HELM HERB HERL HERM HILA HILT HIRE HULA HURL HURT IAMB ILEA ITEM IZAR LAIR LAMA LAMB LAME LARI LATE LATH LATI LATU LAZE LEAR LEHR LIAR LIER LIEU LIMA LIMB LIME LIRA LIRE LITE LITU LUBE LUMA LURE LUTE LUTZ MAAR MABE MAIL MAIR MALE MALT MARA MARE MARL MART MATE MATH MAUL MAUT MAZE MEAL MEAT MELT MERL META METH MILE MILT MIRE MITE MULE MURA MURE MUTE RAIA RAIL RALE RAMI RATE RATH RAZE REAL REAM RHEA RIAL RIEL RILE RIME RITE RITZ RUBE RULE RUTH TABU TAEL TAHR TAIL TALA TALE TALI TAME TARE TEAL TEAM TEAR TELA TERM THAE THEM THIR THRU TIER TILE TIME TIRE TIRL TRAM TRIM TRUE TUBA TUBE TULE TZAR UREA ZEAL ZEBU ZETA

3 letters out of THERALIZUMAB

AAH AAL ABA AHA AHI AIL AIM AIR AIT ALA ALB ALE ALT AMA AMI AMU ARB ARE ARM ART ATE BAA BAH BAL BAM BAR BAT BEL BET BIT BIZ BRA BUM BUR BUT EAR EAT EAU ELM EMU ERA ETA ETH HAE HAM HAT HEM HER HET HIE HIM HIT HUB HUE HUM HUT IRE LAB LAM LAR LAT LEA LEI LET LEU LEZ LIB LIE LIT LUM MAE MAR MAT MEL MET MIB MIL MIR MUT RAH RAI RAM RAT REB REI REM RET RIA RIB RIM RUB RUE RUM RUT TAB TAE TAM TAR TAU TEA TEL THE TIE TIL TUB TUI URB UTA UTE ZIT

2 letters out of THERALIZUMAB

AA AB AE AH AI AL AM AR AT BA BE BI EH EL EM ER ET HA HE HI HM IT LA LI MA ME MI MU RE TA TI UH UM UT ZA

Searching in Dictionaries ...

Definitions of theralizumab in various dictionaries:

THERALIZUMAB - Theralizumab (also known as TGN1412, CD28-SuperMAB, and TAB08) is an immunomodulatory drug developed by Professor Thomas Hünig of the University of ...

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Theralizumab description
Theralizumab (also known as TGN1412, CD28-SuperMAB, and TAB08) is an immunomodulatory drug developed by Professor Thomas Hünig of the University of Würzburg.
* It was withdrawn from development after inducing severe inflammatory reactions in the first-in-human study by PAREXEL in London in March 2006. The developing company, TeGenero Immuno Therapeutics, went bankrupt later that year.
* The commercial rights were then acquired by a Russian startup, TheraMAB. The drug was renamed TAB08. Phase I and II clinical trials have been completed for arthritis and clinical trials have been initiated for cancer.
* Originally intended for the treatment of B cell chronic lymphocytic leukemia (B-CLL) and rheumatoid arthritis, TGN1412 is a humanised monoclonal antibody that not only binds to, but is a strong agonist for, the CD28 receptor of the immune system's T cells. CD28 is the co-receptor for the T cell receptor; It binds to receptors on the interacting partner in the reaction through one of its ligands (B7 family).
* In its first human clinical trials, it caused catastrophic systemic organ failures in the subjects, despite being administered at a supposed sub-clinical dose of 0.1 mg per kg; some 500 times lower than the dose found safe in animals. Six volunteers were hospitalized on 13 March 2006, at least four of these suffering from multiple organ dysfunction. Tentative opinions from an as-yet uncompleted inquiry suggest that the problems resulted from "unforeseen biological action in humans", rather than breach of trial protocols, and the case therefore has had important ramifications for future trials of potentially powerful clinical agents.
* Scientists in early 2007 put forth the theory that the drug acted in a different fashion in humans as compared with the laboratory animals in which the drug was first tried. The severe reactions in humans could have only occurred, they believe, in those with memory T lymphocytes. Animals raised in a sterile lab would presumably have no 'memory' of previous illnesses, thus would not exhibit the severe reactions that occurred in the human subjects. However this is a misunderstanding of the research: the research says that lab animals studied have fewer memory T cells than humans, and that stimulation through the CD28 receptor alone in memory T cells causes them to infiltrate organs and also activates them.The drug, which was designated as an orphan medical product by the European Medicines Agency in March 2005, was developed by TeGenero Immuno Therapeutics, tested by Parexel and manufactured by Boehringer-Ingelheim. TeGenero announced the first elucidation of the molecular structure of CD28 almost exactly one year prior to commencement of the TGN1412 phase I clinical trial.
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