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electrotonu
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There are 11 letters in ELECTROTONU ( C3E1L1N1O1R1T1U1 )
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Definitions of electrotonu in various dictionaries:
ELECTROTONU - In physiology, electrotonus refers to the passive spread of charge inside a neuron. Passive means that voltage-dependent changes in membrane conducta...
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| Originally: a state of altered excitability produced in a nerve by passing an electric current through it. Later also: the passive spread of depolarization along a neurite, neuron, or other excitable cell. |
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In physiology, electrotonus refers to the passive spread of charge inside a neuron. Passive means that voltage-dependent changes in membrane conductance do not contribute. Neurons and other excitable cells produce two types of electrical potential:* Electrotonic potential — a non-propagated local potential, resulting from a local change in ionic conductance (e.g. synaptic or sensory that engenders a local current). When it spreads along a stretch of membrane, it becomes exponentially smaller (decrement). * Action potential — a propagated impulse.Electrotonic potentials represent changes to the neuron's membrane potential that do not lead to the generation of new current by action potentials. Neurons which are small in relation to their length, such as some neurons in the brain, have only electrotonic potentials (starburst amacrine cells in the retina are believed to have these properties); longer neurons utilize electrotonic potentials to trigger the action potential. * The electrotonic potential travels via electrotonic spread, which amounts to attraction of opposite- and repulsion of like-charged ions within the cell. Electrotonic potentials can sum spatially or temporally. Spatial summation is the combination of multiple sources of ion influx (multiple channels within a dendrite, or channels within multiple dendrites), whereas temporal summation is a gradual increase in overall charge due to repeated influxes in the same location. Because the ionic charge enters in one location and dissipates to others, losing intensity as it spreads, electrotonic spread is a graded response. It is important to contrast this with the all-or-none law propagation of the action potential down the axon of the neuron. * Electrotonic spread is generally responsible for increasing the voltage of the soma (neuronal cell body) sufficiently to exceed threshold and trigger the action potential; its summation properties described above make it suitable for integrating input from many different sources. Such input may be depolarizing (positive charge, such as sodium) or hyperpolarizing (negative charge, such as chloride). * Electrotonic potentials are conducted faster than action potentials, but attenuate rapidly so are unsuitable for long-distance signaling. The phenomenon was first discovered by the Eduard Pflüger. |