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indolea
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The answer INDOLEA has 0 possible clue(s) in existing crosswords.
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There are 7 letters in INDOLEA ( A1D2E1I1L1N1O1 )
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Definitions of indolea in various dictionaries:
INDOLEA - Indoleamine-pyrrole 2,3-dioxygenase (IDO or INDO EC 1.13.11.52) is a heme-containing enzyme that in humans is encoded by the IDO1 gene. It is one of ...
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Indoleamine-pyrrole 2,3-dioxygenase (IDO or INDO EC 1.13.11.52) is a heme-containing enzyme that in humans is encoded by the IDO1 gene. It is one of three enzymes that catalyze the first and rate-limiting step in the kynurenine pathway, the O2-dependent oxidation of L-tryptophan to N-formylkynurenine, the others being IDO2 (IDO2) and tryptophan 2,3-dioxygenase (TDO). * IDO has been implicated in immune modulation through its ability to limit T cell function and engage mechanisms of immune tolerance. Emerging evidence suggests that IDO becomes activated during tumor development, helping malignant cells escape eradication by the immune system. |