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chordin
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There are 7 letters in CHORDIN ( C3D2H4I1N1O1R1 )
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Definitions of chordin in various dictionaries:
CHORDIN - Chordin is a bone morphogenetic protein antagonist composed of four small cysteine-rich domains, whose function is not known. Chordin was originally ...
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Chordin description |
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Chordin is a bone morphogenetic protein antagonist composed of four small cysteine-rich domains, whose function is not known. Chordin was originally identified in Xenopus laevis in the laboratory of Edward M. De Robertis as a key developmental protein that dorsalizes early vertebrate embryonic tissues. The polypeptide is 941 amino acids long and 120 kDa large and it dorsalizes the developing embryo by binding ventralizing TGF proteins such as bone morphogenetic proteins. It may also play a role in organogenesis. There are five named isoforms of this protein that are produced by alternative splicing.In mice, Chordin is expressed in the node but not in the anterior visceral endoderm. It has been found to be required for forebrain development. In developing mice that are deficient in both chordin and noggin, the head is nearly absent. This is significant because when only noggin is deficient there are mild defects but the head still forms.In humans, the chordin peptide is encoded by the C |