Welcome to Anagrammer Crossword Genius! Keep reading below to see if nutlik is an answer to any crossword puzzle or word game (Scrabble, Words With Friends etc). Scroll down to see all the info we have compiled on nutlik.
nutlik
Searching in Crosswords ...
The answer NUTLIK has 0 possible clue(s) in existing crosswords.
Searching in Word Games ...
The word NUTLIK is NOT valid in any word game. (Sorry, you cannot play NUTLIK in Scrabble, Words With Friends etc)
There are 6 letters in NUTLIK ( I1K5L1N1T1U1 )
To search all scrabble anagrams of NUTLIK, to go: NUTLIK?
Rearrange the letters in NUTLIK and see some winning combinations
Scrabble results that can be created with an extra letter added to NUTLIK
Searching in Dictionaries ...
Definitions of nutlik in various dictionaries:
No definitions found
Word Research / Anagrams and more ...
Keep reading for additional results and analysis below.
| Nutlik might refer to |
|---|
| Nutlins are cis-imidazoline analogs which inhibit the interaction between mdm2 and tumor suppressor p53, and which were discovered by screening a chemical library by Vassilev et al. Nutlin-1, nutlin-2, and nutlin-3 were all identified in the same screen; however, Nutlin-3 is the compound most commonly used in anti-cancer studies. Nutlin small molecules occupy p53 binding pocket of MDM2 and effectively disrupt the p53–MDM2 interaction that leads to activation of the p53 pathway in p53 wild-type cells. Inhibiting the interaction between mdm2 and p53 stabilizes p53, and is thought to selectively induce a growth-inhibiting state called senescence in cancer cells. These compounds are therefore thought to work best on tumors that contain normal or "wild-type" p53. Nutlin-3 has been shown to affect the production of p53 within minutes.The more potent of the two enantiomers, (−)-nutlin-3, can be synthesized in a highly enantioselective fashion. Several derivatives of nutlin, such as RG7112 and RG7388 (Idasanutlin) have been developed and progressed into human studies. |