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olesom
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There are 6 letters in OLESOM ( E1L1M3O1S1 )
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| Olesom might refer to |
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| Olesoxime (TRO19622) is an experimental neuroprotective drug. It is the lead compound of Trophos' cholesterol-oxime compound family of mitochondrial pore modulators.It is a molecule that has a cholesterol-like structure and displays neuroprotective properties. TRO19622 is as effective as a cocktail of three neurotrophic factors in keeping motor neurons alive in culture.Preclinical studies have demonstrated that the compound promotes the function and survival of neurons and other cell types under disease-relevant stress conditions through interactions with the mitochondrial permeability transition pore (mPTP).A 2009–2011 phase 3 clinical trial of olesoxime in amyotrophic lateral sclerosis did not demonstrate a significant increase in survival versus placebo.The results of a 2011–2013 pivotal trial of olesoxime in spinal muscular atrophy (SMA) indicated that the compound may prevent deterioration of muscle function.In 2015, the olesoxime programme was purchased by Hoffmann-La Roche for €120 million. However, in June 2018, faced with technical and regulatory challenges and competition from a potentially more effective drug Spinraza, Roche announced its decision to halt further development of olesoxime. |