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epots
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There are 5 letters in EPOTS ( E1O1P3S1T1 )
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| Epots might refer to |
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The epothilones are a class of potential cancer drugs. Like taxanes, they prevent cancer cells from dividing by interfering with tubulin, but in early trials epothilones have better efficacy and milder adverse effects than taxanes.As of September 2008, epothilones A to F have been identified and characterised. * Early studies in cancer cell lines and in human cancer patients indicate superior efficacy to the taxanes. Their mechanism of action is similar, but their chemical structure is simpler. Due to their better water solubility, cremophors (solubilizing agents used for paclitaxel which can affect cardiac function and cause severe hypersensitivity) are not needed. * Endotoxin-like properties known from paclitaxel, like activation of macrophages synthesizing inflammatory cytokines and nitric oxide, are not observed for epothilone B.Epothilones were originally identified as metabolites produced by the soil-dwelling myxobacterium Sorangium cellulosum. |