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actom
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There are 5 letters in ACTOM ( A1C3M3O1T1 )
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Definitions of actom in various dictionaries:
ACTOM - The cell cycle is divided into two primary phases: DNA synthesis or S phase and Mitosis or M phase. During the S phase, duplication of chromosomes oc...
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| The cell cycle is divided into two primary phases: DNA synthesis or S phase and Mitosis or M phase. During the S phase, duplication of chromosomes occurs whereas M phase is characterized by two processes known as nuclear (mitosis) and cytoplasmic (cytokinesis) divisions. The Actomyosin ring is a prominent structure during cytoplasmic division or cytokinesis (i.e., splitting from the parent cell after duplication and segregation of the genetic material has been completed). The ring forms perpendicular to the axis of the spindle apparatus. and occurs towards the later stage of mitosis, the telophase, in which sister chromatids are identically separated at the opposite sides of the spindle forming nuclei (see figure 1). The actomyosin ring follows an orderly sequence of identification of active division site, formation of the ring, constriction of the ring, and disassembly of the contractile ring. It is composed of actin and myosin II bundles, thus the term actomyosin, that operates in contractile motion although the mechanism on how or what triggers the constriction is still an evolving topic. Other cytoskeletal proteins are also involved in maintaining stability of the ring. Apart from cytokinesis in which the ring constricts as the cells divide (see figure 2), actomyosin ring constriction has also been found to activate during wound closure. During the process actin filaments are degraded, preserving the thickness of the ring. After cytokinesis is complete, one of the two daughter cells inherits a remnant, called the midbody ring.Activation of the cell-cycle kinase (e.g. Rho-kinases) during telophase initiates constriction of the actomyosin ring by creating a groove that migrates in an inward motion. Rho-kinases such as ROCK1 has been found to regulate actomyosin contraction through phosphorylation of the myosin light chain (MLC). This mechanism promotes cell-cell contacts and integrity leading to adhesion formation. |