Scrabble?! ISIs is valid for Scrabble? Words With Friends? Other games?
Definitions of IS in various dictionaries:
verb - have the quality of being
verb - be identical to
verb - occupy a certain position or area
There are 2 letters in IS ( I1S1 )
To search all scrabble anagrams of IS, to go: IS?
Rearrange the letters in IS and see some winning combinations
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