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nortriptyline

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Definitions of nortriptyline in various dictionaries:

noun - a tricyclic antidepressant drug (trade name Pamelor) used along with psychotherapy to treat dysthymic depression

NORTRIPTYLINE - Nortriptyline, sold under the brand names Allegron, Aventyl, Noritren, Nortrilen, and Pamelor among others, is a tricyclic antidepressant (TCA) used ...

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Possible Dictionary Clues
A tricyclic antidepressant drug, C19H21N.
a tricyclic antidepressant drug (trade name Pamelor) used along with psychotherapy to treat dysthymic depression may interact dangerously if taken with other drugs
A tricyclic antidepressant drug, CHN, with actions and uses similar to those of amitriptyline, and given orally as the hydrochloride.

Nortriptyline description
Nortriptyline, sold under the brand names Allegron, Aventyl, Noritren, Nortrilen, and Pamelor among others, is a tricyclic antidepressant (TCA) used to treat clinical depression. Another licensed use for it is in the treatment of childhood bedwetting. Off-label uses include chronic pain and migraine and labile affect in some neurological disorders. Chemically, it is a secondary amine dibenzocycloheptene and pharmacologically it is classed as a second-generation TCA. * Nortriptyline has less anticholinergic (like dry mouth, constipation, blurred vision, etc.), antihistamine (like sedation and possibly weight gain), antiadrenergic (like orthostatic hypotension), and cardiotoxic (heart-toxic, namely the capacity of these drugs to interfere with normal heart rhythm) effects than the older first-generation TCAs. * Nortriptyline is the major active metabolite of amitriptyline, a first-generation TCA. It is the N-desmethyl metabolite of amitriptyline. Like amitriptyline it works by inhibiting the reuptake of serotonin and norepinephrine, thereby enhancing synaptic signalling via these neurotransmitters. It preferentially inhibits the reuptake of norepinephrine over serotonin, which is the opposite to amitriptyline.*

Nortriptyline description

Nortriptyline, sold under the brand names Allegron, Aventyl, Noritren, Nortrilen, and Pamelor among others, is a tricyclic antidepressant (TCA) used to treat clinical depression. Another licensed use for it is in the treatment of childhood bedwetting. Off-label uses include chronic pain and migraine and labile affect in some neurological disorders. Chemically, it is a secondary amine dibenzocycloheptene and pharmacologically it is classed as a second-generation TCA.
* Nortriptyline has less anticholinergic (like dry mouth, constipation, blurred vision, etc.), antihistamine (like sedation and possibly weight gain), antiadrenergic (like orthostatic hypotension), and cardiotoxic (heart-toxic, namely the capacity of these drugs to interfere with normal heart rhythm) effects than the older first-generation TCAs.
* Nortriptyline is the major active metabolite of amitriptyline, a first-generation TCA. It is the N-desmethyl metabolite of amitriptyline. Like amitriptyline it works by inhibiting the reuptake of serotonin and norepinephrine, thereby enhancing synaptic signalling via these neurotransmitters. It preferentially inhibits the reuptake of norepinephrine over serotonin, which is the opposite to amitriptyline.*

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