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nalorphine
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Definitions of nalorphine in various dictionaries:
noun - a narcotic antagonist (trade name Nalline) that counteracts the effects of narcotics (especially the effects of poisoning by morphine)
NALORPHINE - Nalorphine (INN) (brand names Lethidrone, Nalline), also known as N-allylnormorphine, is a mixed opioid agonistantagonist with opioid antagonist and ...
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| Possible Dictionary Clues |
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| A drug, C19H21NO3, derived from morphine, used to treat respiratory depression and other effects of an overdose of narcotics. |
| a narcotic antagonist (trade name Nalline) that counteracts the effects of narcotics (especially the effects of poisoning by morphine) |
| A synthetic opioid similar to morphine in chemical structure, which acts as a mixed opioid antagonist and agonist and formerly was used in the diagnosis and treatment of narcotic abuse and overdosage ()-(5R,6S)-9a-allyl-4,5-epoxymorphin-7-en-3,6-diol, CHNO. A trademark for this drug in the United States is Nalline. |
| Nalorphine description |
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| Nalorphine (INN) (brand names Lethidrone, Nalline), also known as N-allylnormorphine, is a mixed opioid agonistantagonist with opioid antagonist and analgesic properties. It was introduced in 1954 and was used as an antidote to reverse opioid overdose and in a challenge test to determine opioid dependence. It acts at two opioid receptors the -opioid receptor (MOR) where it has antagonistic effects, and at the -opioid receptor (KOR) (Ki = 1.6 nM; EC50 = 483 nM; Emax = 95%) where it exerts high-efficacy partial agonist/near-full agonist characteristics. Nalorphine was the second opioid antagonist to be introduced, preceded by nalodeine (N-allylnorcodeine) in 1915 and followed by naloxone in 1960 and naltrexone in 1963. Due to potent activation of the KOR, nalorphine produces side effects such as dysphoria, anxiety, confusion, and hallucinations, and for this reason, is no longer used medically. Nalorphine has a number of analogues including niconalorphine (the nicomorphine analogue), di |