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limbed
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The answer LIMBED has 2 possible clue(s) in existing crosswords.
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The word LIMBED is VALID in some board games. Check LIMBED in word games in Scrabble, Words With Friends, see scores, anagrams etc.
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Definitions of limbed in various dictionaries:
adj - having or as if having limbs, especially limbs of a specified kind (usually used in combination)
verb - to cut off the arms or legs of
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having arm-like projections |
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Dec 17 2015 7 Little Words Daily Puzzle |
Dec 17 2015 7 Little Words Daily Puzzle |
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Simple past tense and past participle of limb. |
blimbb. (lm) One of the appendages of an animal, such as an arm of a starfish, the flipper of dolphins, or the arm and leg of a human, used for locomotion or grasping. The expanded tip of a plant organ, such as a petal or corolla lobe. The circumferential edge of the apparent disk of a celestial body. |
having or as if having limbs, especially limbs of a specified kind (usually used in combination) |
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Limb development in vertebrates is an area of active research in both developmental and evolutionary biology, with much of the latter work focused on the transition from fin to limb. Limb formation begins in the morphogenetic limb field, as mesenchymal cells from the lateral plate mesoderm proliferate to the point that they cause the ectoderm above to bulge out, forming a limb bud. Fibroblast growth factor (FGF) induces the formation of an organizer at the end of the limb bud, called the apical ectodermal ridge (AER), which guides further development and controls cell death. Programmed cell death is necessary to eliminate webbing between digits. * The limb field is a region specified by expression of certain Hox genes, a subset of homeotic genes, and T-box transcription factors – Tbx5 for forelimb or wing development, and Tbx4 for leg or hindlimb development. Establishment of the limb field requires retinoic acid signaling in the developing trunk of the embryo from which the limb bud emerges.Limb formation results from series of epithelial-mesenchymal inductions between the mesenchymal cells of the lateral plate mesoderm and the overlying ectodermal cells. Cells from the lateral plate mesoderm and the myotome migrate to the limb field and proliferate to create the limb bud. The lateral plate cells produce the cartilaginous and skeletal portions of the limb while the myotome cells produce the muscle components. The lateral plate mesodermal cells secrete fibroblast growth factors (FGF7 and FGF10) to induce the overlying ectoderm to form AER. The AER secretes FGF8 and FGF4 which maintains the FGF10 signal and induces proliferation in the mesoderm. The position of FGF10 expression is regulated by Wnt8c in the hindlimb and Wnt2b in the forelimb. The forelimb and the hindlimb are specified by their position along the anterior/posterior axis and possibly by two transcription factors: Tbx5 and Tbx4, respectively.The limb bud remains active throughout much of limb development as it stimulates the creation and positive feedback retention of two signaling regions: the AER and its subsequent creation of the zone of polarizing activity (ZPA) with the mesenchymal cells. In addition to the dorsal-ventral axis created by the ectodermal expression of competitive Wnt7a and BMP signals respectively, these AER and ZPA signaling centers are crucial to the proper formation of a limb that is correctly oriented with its corresponding axial polarity in the developing organism. Because these signaling systems reciprocally sustain each other’s activity, limb development is essentially autonomous after these signaling regions have been established. |