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inosine
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Definitions of inosine in various dictionaries:
noun - a nucleoside that is formed by the deamination of adenosine
noun - a compound of hypoxanthine and ribose
INOSINE - Inosine is a nucleoside that is formed when hypoxanthine is attached to a ribose ring (also known as a ribofuranose) via a -N9-glycosidic bond. Inosi...
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A nucleoside formed by the deamination of adenosine or the hydrolysis of inosinic acid. |
Inosine description |
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Inosine is a nucleoside that is formed when hypoxanthine is attached to a ribose ring (also known as a ribofuranose) via a -N9-glycosidic bond. * Inosine is commonly found in tRNAs and is essential for proper translation of the genetic code in wobble base pairs.* Knowledge of inosine metabolism has led to advances in immunotherapy in recent decades. Inosine monophosphate is oxidised by the enzyme inosine monophosphate dehydrogenase, yielding xanthosine monophosphate, a key precursor in purine metabolism. Mycophenolate mofetil is an anti-metabolite, anti-proliferative drug that acts as an inhibitor of inosine monophosphate dehydrogenase. It is used in the treatment of a variety of autoimmune diseases including granulomatosis with polyangiitis because the uptake of purine by actively dividing B cells can exceed 8 times that of normal body cells, and, therefore, this set of white cells (which cannot operate purine salvage pathways) is selectively targeted by the purine deficiency resulting |