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monoclonal

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Definitions of monoclonal in various dictionaries:

noun - any of a class of antibodies produced in the laboratory by a single clone of cells or a cell line and consisting of identical antibody molecules

adj - forming or derived from a single clone

Of, forming, or derived from a single clone: a monoclonal population of tumor cells.

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forming or derived from a single clone
relating to a group of cells that originally come from a single cell:
Forming a clone which is derived asexually from a single individual or cell.
Of, forming, or derived from a single clone: a monoclonal population of tumor cells.
A monoclonal product, especially a monoclonal antibody.

Monoclonal description
Monoclonal cells are a group of cells produced from a single ancestral cell by repeated cellular replication. Thus they can be said to form a single clone. The term monoclonal comes from the Ancient Greek monos, meaning "alone" or "single", and klon, meaning "twig".The process of replication can occur in vivo, or may be stimulated in vitro for laboratory manipulations. The use of the term typically implies that there is some method to distinguish between the cells of the original population from which the single ancestral cell is derived, such as a random genetic alteration, which is inherited by the progeny. * Common usages of this term include:* Monoclonal antibody: A single hybridoma cell, which by chance includes the appropriate V(D)J recombination to produce the desired antibody, is cloned to produce a large population of identical cells. In informal laboratory jargon, the monoclonal antibodies isolated from cell culture supernatants of these hybridoma clones (hybridoma lines) are simply called monoclonals. * Monoclonal neoplasm (tumor): A single aberrant cell which has undergone carcinogenesis reproduces itself into a cancerous mass. * Monoclonal plasma cell (also called plasma cell dyscrasia): A single aberrant plasma cell which has undergone carcinogenesis reproduces itself, which in some cases is cancerous.

Monoclonal description

Monoclonal cells are a group of cells produced from a single ancestral cell by repeated cellular replication. Thus they can be said to form a single clone. The term monoclonal comes from the Ancient Greek monos, meaning "alone" or "single", and klon, meaning "twig".The process of replication can occur in vivo, or may be stimulated in vitro for laboratory manipulations. The use of the term typically implies that there is some method to distinguish between the cells of the original population from which the single ancestral cell is derived, such as a random genetic alteration, which is inherited by the progeny.
* Common usages of this term include:* Monoclonal antibody: A single hybridoma cell, which by chance includes the appropriate V(D)J recombination to produce the desired antibody, is cloned to produce a large population of identical cells. In informal laboratory jargon, the monoclonal antibodies isolated from cell culture supernatants of these hybridoma clones (hybridoma lines) are simply called monoclonals.
* Monoclonal neoplasm (tumor): A single aberrant cell which has undergone carcinogenesis reproduces itself into a cancerous mass.
* Monoclonal plasma cell (also called plasma cell dyscrasia): A single aberrant plasma cell which has undergone carcinogenesis reproduces itself, which in some cases is cancerous.

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