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sequestra
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Definitions of sequestra in various dictionaries:
SEQUESTRA - A sequestrum (plural: sequestra) is a piece of dead bone that has become separated during the process of necrosis from normal or sound bone. It is a ...
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A sequestrum (plural: sequestra) is a piece of dead bone that has become separated during the process of necrosis from normal or sound bone. * It is a complication (sequela) of osteomyelitis. The pathological process is as follows:* infection in the bone leads to an increase in intramedullary pressure due to inflammatory exudates * the periosteum becomes stripped from the osteum, leading to vascular thrombosis * bone necrosis follows due to lack of blood supply * sequestra are formed * The sequestra are surrounded by sclerotic bone which is relatively avascular (without a blood supply). Within the bone itself, the haversian canals become blocked with scar tissue, and the bone becomes surrounded by thickened periosteum. * Due to the avascular nature of this bone, antibiotics which travel to sites of infection via the bloodstream poorly penetrate these tissues, hence the difficulty in treating chronic osteomyelitis. * At the same time as this, new bone is forming (known as involucrum). Openings in thi |