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pyrimethamine
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Definitions of pyrimethamine in various dictionaries:
PYRIMETHAMINE - Pyrimethamine, sold under the trade name Daraprim, is a medication used with leucovorin to treat toxoplasmosis and cystoisosporiasis. It is also used...
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| A drug, C12H13ClN4, used principally in the prophylactic treatment of malaria. |
| Pyrimethamine description |
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Pyrimethamine, sold under the trade name Daraprim, is a medication used with leucovorin to treat toxoplasmosis and cystoisosporiasis. It is also used with dapsone as a second line option to prevent Pneumocystis jiroveci pneumonia (PCP) in people with HIV/AIDS. It was previously used for malaria but is no longer recommended due to resistance. Pyrimethamine is taken by mouth.Common side effects include gastrointestinal upset, severe allergic reactions, bone marrow suppression. It should not be used by people with folate deficiency that has resulted in anemia. There is concern that it may increase the risk of cancer. While occasionally used in pregnancy it is unclear if pyrimethamine is safe for the baby. Pyrimethamine is classified as a folic acid antagonist. It works by inhibiting folic acid metabolism and therefore the making of DNA.Pyrimethamine was discovered in 1952 and came into medical use in 1953. * It is on the World Health Organization's List of Essential Medicines, the most effe |