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The answer TOPHI has 2 possible clue(s) in existing crosswords.
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The word TOPHI is VALID in some board games. Check TOPHI in word games in Scrabble, Words With Friends, see scores, anagrams etc.
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Definitions of tophi in various dictionaries:
noun - a deposit of urates in the tissue around a joint
TOPHI - A tophus (Latin: "stone", plural tophi) is a deposit of uric acid crystals, in the form of monosodium urate crystals, in people with longstanding hyp...
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Keep reading for additional results and analysis below.
|Possible Crossword Clues|
|Indications of gout hard to conceal with hat|
|Such may arrive with gout - hop with it perhaps?|
|Last Seen in these Crosswords & Puzzles|
|Apr 25 2003 The Times - Cryptic|
|Jun 29 2002 The Times - Cryptic|
A tophus (Latin: "stone", plural tophi) is a deposit of uric acid crystals, in the form of monosodium urate crystals, in people with longstanding hyperuricemia (high levels of uric acid in the blood). Tophi are pathognomonic for the disease gout. Most people with tophi have had previous attacks of acute arthritis, eventually leading to the formation of tophi. Chronic tophaceous gout is known as Harrison Syndrome.|
* Tophi form in the joints, cartilage, bones, and other places throughout the body. Sometimes, tophi break through the skin and appear as white or yellowish-white, chalky nodules. Without treatment, tophi may develop on average about ten years after the onset of gout, although their first appearance can range from three to forty-two years. The development of gouty tophi can also limit joint function and cause bone destruction, leading to noticeable disabilities, especially when gout cannot successfully be treated. When uric acid levels and gout symptoms cannot be controlled with