Scrabble?! CAUSALGIC

Definitions of CAUSALGIC in various dictionaries:

Complex Regional Pain Syndrome (CRPS), also known as Reflex Sympathetic Dystrophy (RSD), is a disorder of a portion of the body, usually starting in a limb, which manifests as extreme pain, swelling, limited range of motion, and changes to the skin and bones. It may initially affect one limb and then spread throughout the body; 35% of affected people report symptoms throughout their whole bodies. There are multiple names for this disease, as well as two subtypes. Type I (originally called Reflex Sympathetic Dystrophy/RSD) occurs after an illness or injury with no direct evidence of nerve damage in the affected limb. This is approximately 90% of CRPS patients. Type II (Causalgia) has distinct evidence of a nerve injury.Complex Regional Pain Syndrome is uncommon, and its cause isn't clearly understood. Treatment is most effective when started early. In such cases, improvement and even remission are possible. CRPS typically develops after an injury, surgery, heart attack, or stroke. The pain is out of proportion to the initial event.[1] It is proposed that inflammation and alteration of pain perception in the central nervous system play important roles. It has been suggested that persistent pain and the perception of non-painful stimuli as painful may be caused by inflammatory molecules (IL-1, IL2, TNF-alpha) and neuropeptides (substance P) released from peripheral nerves. This release may be caused by inappropriate cross talk between sensory and motor fibers at the affected site. CRPS is not a psychological illness, yet pain can cause psychological problems, such as anxiety and depression. There is often impaired social and occupational function.Treatment involves a multidisciplinary approach involving medications, physical and occupational therapy, psychological treatments, and neuromodulation. Despite this, the results are often unsatisfactory, especially if treatment is delayed. Treatment is most effective when started early in the course of the illness. [2]